Novus DNA Metabolic+ is a dual-action AMPK-activating formula designed to support metabolic flexibility, optimise how your body handles sugar and fat, strengthen liver performance, and sustain clean, steady energy throughout the day.

Each serving combines two clinically proven botanicals in evidence-based doses:

• Berberine HCl (500 mg, 97 % purity, from Berberis aristata) – a plant alkaloid with a long history of use in traditional medicine and now widely studied for its impact on blood sugar, lipids, and metabolic health. Human clinical trials and meta-analyses show it can:

Lower fasting blood sugar and HbA1c (a long-term glucose marker) almost as effectively as metformin

Improve cholesterol and triglyceride levels (average LDL reduction ≈ 20–25 %, triglycerides ≈ 30–35 %)

Activate AMPK, the body’s “metabolic master switch,” helping improve insulin sensitivity, and reduce new fat production in the liver

These effects can translate into a smaller waistline, steadier energy, and better overall metabolic balance.

• Milk Thistle Extract (250 mg, 80 % silymarin, 30 % silybin)

Milk thistle (Silybum marianum) has been used for centuries to support liver health. Its active complex, silymarin – and particularly silybin – helps shield liver cells from oxidative stress, support regeneration, and improve how the liver processes fats and toxins more efficiently. Studies show it can:

Increase antioxidant protection and reduce liver enzyme markers (ALT and AST)

Support healthier liver structure and function in those with fatty liver and metabolic challenges

Enhance bile flow, supporting digestion and the clearance of waste products

By pairing berberine with a high-potency milk thistle extract, Metabolic+ not only helps control sugar and lipids but also supports the organ that sits at the centre of metabolic regulation – your liver.

Why AMPK Activation Matters

AMP-activated protein kinase (AMPK) is often described as a central metabolic energy sensor in the body. When AMPK is activated, it signals your cells to:

Burn more stored fat for energy

Increase glucose uptake into muscles

Reduce new fat and cholesterol synthesis in the liver

Improve insulin sensitivity

Berberine is one of the most researched natural AMPK activators. By activating this pathway, Metabolic+ supports a metabolic profile associated with improved blood sugar, reduced visceral fat, and more efficient fuel use.

Metabolic+, Nutrition and Lifestyle

Metabolic+ works best as part of a comprehensive approach to metabolic health that includes regular movement, strength training, prioritising whole foods, adequate protein intake, and minimising ultra-processed carbohydrates and sugars.

Who Metabolic+ is For

Adults who want proactive support for healthy blood sugar and insulin sensitivity

Those seeking to support their liver health, especially in the context of a modern lifestyle

People noticing stubborn weight, particularly around the midsection, despite reasonable diet and activity

Anyone aiming to support long-term cardiometabolic health in a research-backed, targeted way

Everyday Benefits

Steadier energy all day (no mid-afternoon crashes)

Easier weight control, especially around the belly

Healthier blood sugar and cholesterol levels

Cleaner, more efficient liver function supporting detox and digestion

Sharper mental focus thanks to balanced energy metabolism

Better long-term metabolic protection for those managing blood sugar or fatty liver concerns