NR CL is a well-studied, highly bioavailable precursor to NAD+ – a central coenzyme required for over 500 cellular reactions, including energy production, DNA repair, and cellular stress responses. Human trials have shown that NR supplementation can significantly raise NAD+ levels, which naturally decline with age.

Elevated NAD+ has been associated with:

Improved mitochondrial function and ATP production

Enhanced cellular resilience to stress

Support for sirtuin activity (a family of proteins linked to cellular ageing and metabolic health)

Pterostilbene, a dimethylated analogue of resveratrol, offers greater bioavailability and more stable plasma levels than resveratrol. It has been investigated for its potential to support cellular antioxidant defences, modulate inflammatory signalling, and contribute to cardiovascular and neuroprotective benefits.

Trimethylglycine (TMG, also known as betaine) plays a key role in methylation – a fundamental process involved in DNA repair, detoxification, neurotransmitter production, and homocysteine regulation. Combined with NR, TMG helps maintain methylation balance while supporting NAD+ synthesis pathways.

Piperine is included in Longevity+ to enhance the bioavailability of NR CL and pterostilbene by modulating intestinal absorption and slowing metabolic clearance. This can help support more consistent and sustained elevations in NAD+ and active polyphenol levels.

Why NAD+ Matters

NAD+ (nicotinamide adenine dinucleotide) is required by virtually every cell for:

Energy production in the mitochondria

DNA repair through PARP enzymes

Regulation of cellular stress responses and longevity pathways like sirtuins

Healthy metabolic signalling

As we age, NAD+ levels can decline, which may impact how effectively our cells generate energy, repair damage, and maintain resilience under stress. Supporting NAD+ with NR CL, alongside methylation support from TMG and antioxidant support from pterostilbene, offers a multi-angle approach to healthy ageing.

Longevity+ and Daily Living

Longevity+ is designed as a long-term support formula for those looking to invest in cellular health, energy, and cognitive performance. It is not a stimulant and does not provide a short-lived “buzz.” Instead, it supports the cellular machinery that underpins sustainable energy, mental clarity, and resilience over time.

Who Longevity+ is For

Adults interested in supporting healthy ageing at the cellular level

Those experiencing low energy, mental fatigue, or slower recovery from daily stressors

People with demanding cognitive workloads who want to support brain health and focus

Anyone looking to proactively support mitochondrial function, DNA repair, and metabolic health